Proposal for Training to Conduct a Clinical Study
On the Effects of Propolis Bee Tincture
And The Treatment of Gingivitis
Dr. Dana Vieru York, DDS, MS, PhDc, Periodontist)
Faculty, Cariology Department, NYU College of Dentistry
The general objective of this training plan is to study methods of collecting, analyzing and presenting data in a form suitable for peer review publication. The trials relevant to inculcate the necessary methods and principles for valid clinical research relate to the topical application of propolis bee tincture among diverse populations in the treatment of gingivitis.
The proposed training will first lay the intellectual groundwork to conceive and design valid studies that would demonstrate whether subjects receiving topical propolis bee tinctures in addition to traditional treatment exhibit better recovery and healing than subjects treated without – e.g. cessation of bleeding and shortened pain recovery time and reduction of inflammation.
We would study the significance of sampling, the proper practices and pitfalls of recruiting patients and the necessity to standardize diagnoses of the advancement of gingivitis and the means by which to do it.
We would study the principles and consequences of grouping patients such as (1) diabetic with propolis and (2) diabetic without propolis and 3) healthy individuals with gingivitis.
We will train to determine the mean and standard deviations of such factors as:
1. Bleeding time. We will consider gingival bleeding time as the time interval from the end of the curettage until the formation of the blood clot, established by the paper test. The time will be measured with a chronometer. The measurement will be performed in one location.
2. Pain relief time. Pain is a physiological consequence of the surgical trauma, accompanied by inflammation. We will ask the patients to note the evolution of the pain intensity, whether they can use the maxillaries for normal mastication. The time interval described by the patient until the complete resolution of pain will be measured.
3. The recurrence rate will be monitored and statistically quantified by the numbers.
The objective of the proposed training will be to develop the expertise to determine the parameters of significant factors as well as to account for the foregoing in a scientifically useful manner.
The training would provide competent guidance in the selection of a protocol.
In a study that would result from the training plan, participating patients would benefit from the classical modern dental treatment of gingivitis. We seek to learn how to determine whether patients would further benefit when treated, in addition, with propolis bee tincture.
We expect the proposed training to elucidate how the rigorous application of the scientific method alone can lead to responsible advocacy for or against a topically administered propolis modality for treatment of gingivitis, which, when sufficiently studied, may support an economical, non-invasive treatment of inflammation concurrent with gingival infection.
The effects will be studied of collecting clinical data from patient cards from multiple sites.
Statistical evidence measurements and protocols will be conceived and conducted at the Department of Cariology and Comprehensive Care, NYU College of Dentistry.
Training for research will take place at the Department of Cariology and Comprehensive Care, New York University College of Dentistry.
This study will neither require clinical space from school facilities nor time away from teaching.